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In addition to Fake-constructive success, heterophile antibodies can cause falsely lower success should they bind towards the variable regions in the seize antibody, mimicking the antigen for being measured and protecting against troponin from binding.[89] The most often utilised method for minimizing the affect of HAMA on business immunoassays may be the addition of non-immune mouse immunoglobulin (IgG).
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Two challenges Restrict the benefit of switching from 1 troponin assay to a different in medical follow or investigation. Very first, no primary reference cTnI product is available for companies to standardize cTnI assays.
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